Natural Products and Gastric Cancer: Cellular Mechanisms and Effects to Change Cancer Progression


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Abstract

Gastric cancer is a severe malignant tumor with high morbidity and mortality, which seriously affects people's health. At present, the most common treatment for gastric cancer is chemotherapy. However, chemotherapy is very harmful to the human body, and some of the injuries caused by chemotherapy are irreversible. Natural products have low toxicity and anti-cancer activity, so they are currently widely studied at present. Natural products are a large variety of compounds naturally found in fruits, vegetables, spices, and medicinal plants. It is reported that natural products have different anti-cancer properties. This review has summarized the study of natural products in inducing gastric cancer cell apoptosis, inhibiting gastric cancer cell metastasis, and inhibiting gastric cancer cell proliferation. The relevant references on gastric cancer and natural products were obtained from scientific databases, including PubMed, Web of Science, and Science Direct. This paper records dozens of natural products with anti-gastric tumor activity and describes the potential living anti-cancer chemical compounds, their element targets, and their underlying mechanism. This review may lay the foundation for future researchers to treat gastric cancer

About the authors

Ning Zhao

College of Life Science, Liaoning University

Email: info@benthamscience.net

Wendi Wang

College of Life Science, Liaoning University

Email: info@benthamscience.net

Haoyue Jiang

College of Life Science, Liaoning University

Email: info@benthamscience.net

Zhengkang Qiao

College of Life Science, Liaoning University

Email: info@benthamscience.net

Shiming Sun

College of Life Science, Liaoning University

Email: info@benthamscience.net

Yang Wei

College of Life Science, Liaoning University

Email: info@benthamscience.net

Xinru Xie

College of Life Science, Liaoning University

Email: info@benthamscience.net

Hui Li

College of Life Science, Liaoning University

Author for correspondence.
Email: info@benthamscience.net

Xiuli Bi

College of Life Science, Liaoning University

Author for correspondence.
Email: info@benthamscience.net

Zhe Yang

College of Life Science, Liaoning University

Author for correspondence.
Email: info@benthamscience.net

References

  1. Bray, F.; Ferlay, J.; Soerjomataram, I.; Siegel, R.L.; Torre, L.A.; Jemal, A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin., 2018, 68(6), 394-424. doi: 10.3322/caac.21492 PMID: 30207593
  2. Crew, K.D.; Neugut, A.I. Epidemiology of gastric cancer. World J. Gastroenterol., 2006, 12(3), 354-362. doi: 10.3748/wjg.v12.i3.354 PMID: 16489633
  3. Karimi, P.; Islami, F.; Anandasabapathy, S.; Freedman, N.D.; Kamangar, F. Gastric cancer: Descriptive epidemiology, risk factors, screening, and prevention. Cancer Epidemiol. Biomarkers Prev., 2014, 23(5), 700-713. doi: 10.1158/1055-9965.EPI-13-1057 PMID: 24618998
  4. Chung, M.Y.; Lim, T.G.; Lee, K.W. Molecular mechanisms of chemopreventive phytochemicals against gastroenterological cancer development. World J. Gastroenterol., 2013, 19(7), 984-993. doi: 10.3748/wjg.v19.i7.984 PMID: 23467658
  5. Katz, L.; Baltz, R.H. Natural product discovery: Past, present, and future. J. Ind. Microbiol. Biotechnol., 2016, 43(2-3), 155-176. doi: 10.1007/s10295-015-1723-5 PMID: 26739136
  6. Mondal, S.; Bandyopadhyay, S.; Ghosh, M.K.; Mukhopadhyay, S.; Roy, S.; Mandal, C. Natural products: promising resources for cancer drug discovery. Anticancer. Agents Med. Chem., 2012, 12(1), 49-75. doi: 10.2174/187152012798764697 PMID: 21707502
  7. Pratheeshkumar, P.; Sreekala, C.; Zhang, Z.; Budhraja, A.; Ding, S.; Son, Y.O.; Wang, X.; Hitron, A.; Hyun-Jung, K.; Wang, L.; Lee, J.C.; Shi, X. Cancer prevention with promising natural products: Mechanisms of action and molecular targets. Anticancer. Agents Med. Chem., 2012, 12(10), 1159-1184. doi: 10.2174/187152012803833035 PMID: 22583402
  8. Kim, C.; Kim, B. Anti-cancer natural products and their bioactive compounds inducing ER stress-mediated apoptosis: A review. Nutrients, 2018, 10(8), 1021. doi: 10.3390/nu10081021 PMID: 30081573
  9. Azab, A.; Nassar, A.; Azab, A. Anti-Inflammatory Activity of Natural Products. Molecules, 2016, 21(10), 1321. doi: 10.3390/molecules21101321 PMID: 27706084
  10. Sznarkowska, A.; Kostecka, A.; Meller, K.; Bielawski, K.P. Inhibition of cancer antioxidant defense by natural compounds. Oncotarget, 2017, 8(9), 15996-16016. doi: 10.18632/oncotarget.13723 PMID: 27911871
  11. Khalid, E.B.; Ayman, E.L.M.E.L.K.; Rahman, H.; Abdelkarim, G.; Najda, A. Natural products against cancer angiogenesis. Tumour Biol., 2016, 37(11), 14513-14536. doi: 10.1007/s13277-016-5364-8 PMID: 27651162
  12. Siu, D. Natural products and their role in cancer therapy. Med. Oncol., 2011, 28(3), 888-900. doi: 10.1007/s12032-010-9528-x PMID: 20414819
  13. Demain, A.L.; Vaishnav, P. Natural products for cancer chemotherapy. Microb. Biotechnol., 2011, 4(6), 687-699. doi: 10.1111/j.1751-7915.2010.00221.x PMID: 21375717
  14. Yuan, R.; Hou, Y.; Sun, W.; Yu, J.; Liu, X.; Niu, Y.; Lu, J.J.; Chen, X. Natural products to prevent drug resistance in cancer chemotherapy: A review. Ann. N. Y. Acad. Sci., 2017, 1401(1), 19-27. doi: 10.1111/nyas.13387 PMID: 28891091
  15. Bao, C.; Kramata, P.; Lee, H.J.; Suh, N. Regulation of Hedgehog signaling in cancer by natural and dietary compounds. Mol. Nutr. Food Res., 2018, 62(1), 1700621. doi: 10.1002/mnfr.201700621 PMID: 29164817
  16. Zhang, J.Y.; Lin, M.T.; Zhou, M.J.; Yi, T.; Tang, Y.N.; Tang, S.L.; Yang, Z.J.; Zhao, Z.Z.; Chen, H.B. Combinational treatment of curcumin and quercetin against gastric cancer MGC-803 cells in vitro. Molecules, 2015, 20(6), 11524-11534. doi: 10.3390/molecules200611524 PMID: 26111180
  17. Koosirirat, C.; Linpisarn, S.; Changsom, D.; Chawansuntati, K.; Wipasa, J. Investigation of the anti-inflammatory effect of Curcuma longa in Helicobacter pylori-infected patients. Int. Immunopharmacol., 2010, 10(7), 815-818. doi: 10.1016/j.intimp.2010.04.021 PMID: 20438867
  18. Zhang, X.; Zhang, C.; Ren, Z.; Zhang, F.; Xu, J.; Zhang, X.; Zheng, H. Curcumin affects gastric cancer cell migration, invasion and cytoskeletal remodeling through Gli1-β-. Catenin. Cancer Manag. Res., 2020, 12, 3795-3806. doi: 10.2147/CMAR.S244384 PMID: 32547215
  19. Sun, Q.; Zhang, W.; Guo, Y.; Li, Z.; Chen, X.; Wang, Y.; Du, Y.; Zang, W.; Zhao, G. Curcumin inhibits cell growth and induces cell apoptosis through upregulation of miR-33b in gastric cancer. Tumour Biol., 2016, 37(10), 13177-13184. doi: 10.1007/s13277-016-5221-9 PMID: 27456358
  20. Liang, Z.; Wu, R.; Xie, W.; Geng, H.; Zhao, L.; Xie, C.; Wu, J.; Geng, S.; Li, X.; Zhu, M.; Zhu, W.; Zhu, J.; Huang, C.; Ma, X.; Zhong, C.; Han, H. Curcumin suppresses MAPK pathways to reverse tobacco smoke-induced gastric epithelial-mesenchymal transition in Mice. Phytother. Res., 2015, 29(10), 1665-1671. doi: 10.1002/ptr.5398 PMID: 26074474
  21. Da, W.; Zhang, J.; Zhang, R.; Zhu, J. Curcumin inhibits the lymphangiogenesis of gastric cancer cells by inhibiton of HMGB1/VEGF-D signaling. Int. J. Immunopathol. Pharmacol., 2019, 33. doi: 10.1177/2058738419861600 PMID: 31266378
  22. Wang, X.P.; Wang, Q.X.; Lin, H.P.; Chang, N. Anti-tumor bioactivities of curcumin on mice loaded with gastric carcinoma. Food Funct., 2017, 8(9), 3319-3326. doi: 10.1039/C7FO00555E PMID: 28848967
  23. Fu, H.; Wang, C.; Yang, D.; Wei, Z.; Xu, J.; Hu, Z.; Zhang, Y.; Wang, W.; Yan, R.; Cai, Q. Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling. J. Cell. Physiol., 2018, 233(6), 4634-4642. doi: 10.1002/jcp.26190 PMID: 28926094
  24. Liu, G.; Xiang, T.; Wu, Q.F.; Wang, W.X. Curcumin suppresses the proliferation of gastric cancer cells by downregulating H19. Oncol. Lett., 2016, 12(6), 5156-5162. doi: 10.3892/ol.2016.5354 PMID: 28105222
  25. Qin, H. B.; Wei, L.; Zhang, J. W.; Tang, J. M. Study on functions and mechanism of curcumin in inducing gastric carcinoma BGC apoptosis. Chinese J. cellul. Molecule. immunol., 2011, 27(11), 1227-30.
  26. Weng, Q.; Fu, L.; Chen, G.; Hui, J.; Song, J.; Feng, J.; Shi, D.; Cai, Y.; Ji, J.; Liang, G. Design, synthesis, and anticancer evaluation of long-chain alkoxylated mono-carbonyl analogues of curcumin. Eur. J. Med. Chem., 2015, 103, 44-55. doi: 10.1016/j.ejmech.2015.08.036 PMID: 26318057
  27. Zhou, S.; Yao, D.; Guo, L.; Teng, L. Curcumin suppresses gastric cancer by inhibiting gastrin-mediated acid secretion. FEBS Open Bio, 2017, 7(8), 1078-1084. doi: 10.1002/2211-5463.12237 PMID: 28781948
  28. Haghi, A.; Azimi, H.; Rahimi, R. A Comprehensive review on pharmacotherapeutics of three phytochemicals, curcumin, quercetin, and allicin, in the treatment of gastric cancer. J. Gastrointest. Cancer, 2017, 48(4), 314-320. doi: 10.1007/s12029-017-9997-7 PMID: 28828709
  29. Yu, L.L.; Wu, J.G.; Dai, N.; Yu, H.G.; Si, J.M. Curcumin reverses chemoresistance of human gastric cancer cells by downregulating the NF-κB transcription factor. Oncol. Rep., 2011, 26(5), 1197-1203. doi: 10.3892/or.2011.1410 PMID: 21811763
  30. He, W.; Xia, Y.; Cao, P.; Hong, L.; Zhang, T.; Shen, X.; Zheng, P.; Shen, H.; Liang, G.; Zou, P. Curcuminoid WZ35 synergize with cisplatin by inducing ROS production and inhibiting TrxR1 activity in gastric cancer cells. J. Exp. Clin. Cancer Res., 2019, 38(1), 207. doi: 10.1186/s13046-019-1215-y PMID: 31113439
  31. Chen, X.; Chen, X.; Zhang, X.; Wang, L.; Cao, P.; Rajamanickam, V.; Wu, C.; Zhou, H.; Cai, Y.; Liang, G.; Wang, Y. Curcuminoid B63 induces ROS-mediated paraptosis-like cell death by targeting TrxR1 in gastric cells. Redox Biol., 2019, 21, 101061. doi: 10.1016/j.redox.2018.11.019 PMID: 30590310
  32. Tang, X.; Bi, H.; Feng, J.; Cao, J. Effect of curcumin on multidrug resistance in resistant human gastric carcinoma cell line SGC7901/VCR. Acta Pharmacol. Sin., 2005, 26(8), 1009-1016. doi: 10.1111/j.1745-7254.2005.00149.x PMID: 16038636
  33. Sun, C.; Zhang, S.; Liu, C.; Liu, X. Curcumin promoted miR-34a expression and suppressed proliferation of gastric cancer cells. Cancer Biother. Radiopharm., 2019, 34(10), 634-641. doi: 10.1089/cbr.2019.2874 PMID: 31539270
  34. Gao, C.; Ding, Z.; Liang, B.; Chen, N.; Cheng, D. Study on the effects of curcumin on angiogenesis. Zhong Yao Cai, 2003, 26(7), 499-502. PMID: 14650061
  35. Lee, H.; Lee, S.; Shin, Y.; Cho, M.; Kang, H.; Cho, H. Anti-cancer effect of quercetin in Xenograft models with EBV-associated human gastric carcinoma. Molecules, 2016, 21(10), 1286. doi: 10.3390/molecules21101286 PMID: 27681719
  36. Yu, Z.J.; He, L.Y.; Chen, Y.; Wu, M.Y.; Zhao, X.H.; Wang, Z.Y. Effects of quercetin on the expression of VEGF-C and VEGFR-3 in human cancer MGC-803 cells. Xi bao yu fen zi mian yi xue za zhi = Chinese J. Cell. Mol. Immunol., 2009, 25(8), 678-680.
  37. Xu, Y.X.; Wang, B.; Zhao, X.H. In vitro effects and the related molecular mechanism of galangin and quercetin on human gastric cancer cell line (SGC-7901). Pak. J. Pharm. Sci., 2017, 30(4), 1279-1287. PMID: 29039326
  38. Qin, Y.; He, L.Y.; Chen, Y.; Wang, W.Y.; Zhao, X.H.; Wu, M.Y. Quercetin affects leptin and its receptor in human gastric cancer MGC-803 cells and JAK-STAT pathway. Xi bao yu fen zi mian yi xue za zhi = Chinese J. Cell. Mol. Immunol., 2012, 28(1), 12-16.
  39. Lei, C.S.; Hou, Y.C.; Pai, M.H.; Lin, M.T.; Yeh, S.L. Effects of quercetin combined with anticancer drugs on metastasis-associated factors of gastric cancer cells: in vitro and in vivo studies. J. Nutr. Biochem., 2018, 51, 105-113. doi: 10.1016/j.jnutbio.2017.09.011 PMID: 29125991
  40. Borska, S.; Chmielewska, M.; Wysocka, T.; Drag-Zalesinska, M.; Zabel, M.; Dziegiel, P. In vitro effect of quercetin on human gastric carcinoma: Targeting cancer cells death and MDR. Food Chem. Toxicol., 2012, 50(9), 3375-3383. doi: 10.1016/j.fct.2012.06.035 PMID: 22750388
  41. Hyun, H.; Moon, J.; Cho, S. Quercetin suppresses CYR61-Mediated multidrug resistance in human gastric adenocarcinoma AGS Cells. Molecules, 2018, 23(2), 209. doi: 10.3390/molecules23020209 PMID: 29364834
  42. Li, H.; Chen, C. Quercetin has antimetastatic effects on gastric cancer cells via the interruption of uPA/uPAR function by modulating NF-κb, PKC-δ ERK1/2, and AMPKα. Integr. Cancer Ther., 2018, 17(2), 511-523. doi: 10.1177/1534735417696702 PMID: 28627240
  43. Shang, H.S.; Lu, H.F.; Lee, C.H.; Chiang, H.S.; Chu, Y.L.; Chen, A.; Lin, Y.F.; Chung, J.G. Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells. Environ. Toxicol., 2018, 33(11), 1168-1181. doi: 10.1002/tox.22623 PMID: 30152185
  44. Yoshida, M.; Sakai, T.; Hosokawa, N.; Marui, N.; Matsumoto, K.; Fujioka, A.; Nishino, H.; Aoike, A. The effect of quercetin on cell cycle progression and growth of human gastric cancer cells. FEBS Lett., 1990, 260(1), 10-13. doi: 10.1016/0014-5793(90)80053-L PMID: 2298289
  45. Wang, P.; Zhang, K.; Zhang, Q.; Mei, J.; Chen, C.; Feng, Z.; Yu, D. Effects of quercetin on the apoptosis of the human gastric carcinoma cells. Toxicol. In Vitro, 2012, 26(2), 221-228. doi: 10.1016/j.tiv.2011.11.015 PMID: 22222411
  46. Zhang, S.; Huang, J.; Xie, X.; He, Y.; Mo, F.; Luo, Z. Quercetin from Polygonum capitatum protects against gastric inflammation and apoptosis associated with Helicobacter pylori infection by affecting the levels of p38MAPK, BCL-2 and BAX. Molecules, 2017, 22(5), 744. doi: 10.3390/molecules22050744 PMID: 28481232
  47. Kim, M.C.; Lee, H.J.; Lim, B.; Ha, K.T.; Kim, S.Y.; So, I.; Kim, B.J. Quercetin induces apoptosis by inhibiting MAPKs and TRPM7 channels in AGS cells. Int. J. Mol. Med., 2014, 33(6), 1657-1663. doi: 10.3892/ijmm.2014.1704 PMID: 24647664
  48. Wang, H.Y.; Guo, L.M.; Chen, Y.; Zhao, X.H.; Cheng, C.L.; Wu, M.Y.; He, L.Y. Quercetin inhibits growth and induces apoptosis of human gastric carcinoma cells. Xi bao yu fen zi mian yi xue za zhi = Chinese J. Cell. Mol. Immunol., 2006, 22(5), 585-587.
  49. Wang, K.; Liu, R.; Li, J.; Mao, J.; Lei, Y.; Wu, J.; Zeng, J.; Zhang, T.; Wu, H.; Chen, L.; Huang, C.; Wei, Y. Quercetin induces protective autophagy in gastric cancer cells: Involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling. Autophagy, 2011, 7(9), 966-978. doi: 10.4161/auto.7.9.15863 PMID: 21610320
  50. Yang, L.; Hu, Z.; Zhu, J.; Liang, Q.; Zhou, H.; Li, J.; Fan, X.; Zhao, Z.; Pan, H.; Fei, B. Systematic elucidation of the mechanism of quercetin against gastric cancer via network pharmacology approach. BioMed Res. Int., 2020, 2020, 3860213. doi: 10.1155/2020/3860213 PMID: 32964029
  51. Zhou, H.B.; Chen, J.J.; Wang, W.X.; Cai, J.T.; Du, Q. Anticancer activity of resveratrol on implanted human primary gastric carcinoma cells in nude mice. World J. Gastroenterol., 2005, 11(2), 280-284. doi: 10.3748/wjg.v11.i2.280 PMID: 15633232
  52. Xu, Q.H.; Xiao, Y.; Li, X.Q.; Fan, L.; Zhou, C.C.; Cheng, L.; Jiang, Z.D.; Wang, G.H. Resveratrol counteracts hypoxia-induced gastric cancer invasion and EMT through hedgehog pathway suppression. Anticancer. Agents Med. Chem., 2020, 20(9), 1105-1114. doi: 10.2174/1871520620666200402080034 PMID: 32238142
  53. Riles, W.L.; Erickson, J.; Nayyar, S.; Atten, M.J.; Attar, B.M.; Holian, O. Resveratrol engages selective apoptotic signals in gastric adenocarcinoma cells. World J. Gastroenterol., 2006, 12(35), 5628-5634. doi: 10.3748/wjg.v12.i35.5628 PMID: 17007014
  54. Kim, S.; Kim, W.; Kim, D.H.; Jang, J.H.; Kim, S.J.; Park, S.A.; Hahn, H.; Han, B.W.; Na, H.K.; Chun, K.S.; Choi, B.Y.; Surh, Y.J. Resveratrol suppresses gastric cancer cell proliferation and survival through inhibition of PIM-1 kinase activity. Arch. Biochem. Biophys., 2020, 689, 108413. doi: 10.1016/j.abb.2020.108413 PMID: 32473133
  55. Shin, K.O.; Park, N.Y.; Seo, C.H.; Hong, S.P.; Oh, K.W.; Hong, J.T.; Han, S.K.; Lee, Y.M. Inhibition of sphingolipid metabolism enhances resveratrol chemotherapy in human gastric cancer cells. Biomol. Ther., 2012, 20(5), 470-476. doi: 10.4062/biomolther.2012.20.5.470 PMID: 24009836
  56. Yin, L.; Zhang, R.; Hu, Y.; Li, W.; Wang, M.; Liang, Z.; Sun, Z.; Ji, R.; Xu, W.; Qian, H. Gastric-cancer-derived mesenchymal stem cells: a promising target for resveratrol in the suppression of gastric cancer metastasis. Hum. Cell, 2020, 33(3), 652-662. doi: 10.1007/s13577-020-00339-5 PMID: 32350750
  57. Xu, J.; Liu, D.; Niu, H.; Zhu, G.; Xu, Y.; Ye, D.; Li, J.; Zhang, Q. Resveratrol reverses Doxorubicin resistance by inhibiting epithelial-mesenchymal transition (EMT) through modulating PTEN/Akt signaling pathway in gastric cancer. J. Exp. Clin. Cancer Res., 2017, 36(1), 19. doi: 10.1186/s13046-016-0487-8 PMID: 28126034
  58. Gao, Q.; Yuan, Y.; Gan, H.Z.; Peng, Q. Resveratrol inhibits the hedgehog signaling pathway and epithelial-mesenchymal transition and suppresses gastric cancer invasion and metastasis. Oncol. Lett., 2015, 9(5), 2381-2387. doi: 10.3892/ol.2015.2988 PMID: 26137075
  59. Yang, Z.; Xie, Q.; Chen, Z.; Ni, H.; Xia, L.; Zhao, Q.; Chen, Z.; Chen, P. Resveratrol suppresses the invasion and migration of human gastric cancer cells via inhibition of MALAT1-mediated epithelial-to-mesenchymal transition. Exp. Ther. Med., 2019, 17(3), 1569-1578. PMID: 30783423
  60. Slattery, M.L.; Benson, J.; Curtin, K.; Ma, K.N.; Schaeffer, D.; Potter, J.D. Carotenoids and colon cancer. Am. J. Clin. Nutr., 2000, 71(2), 575-582. doi: 10.1093/ajcn/71.2.575 PMID: 10648274
  61. Milani, A.; Basirnejad, M.; Shahbazi, S.; Bolhassani, A. Carotenoids: Biochemistry, pharmacology and treatment. Br. J. Pharmacol., 2017, 174(11), 1290-1324. doi: 10.1111/bph.13625 PMID: 27638711
  62. Kim, J.H.; Lee, J.; Choi, I.J.; Kim, Y.I.; Kwon, O.; Kim, H.; Kim, J. Dietary carotenoids intake and the risk of gastric cancer: A case-control study in Korea. Nutrients, 2018, 10(8), 1031. doi: 10.3390/nu10081031 PMID: 30087311
  63. Li, P.; Zhang, H.; Chen, J.; Shi, Y.; Cai, J.; Yang, J.; Wu, Y. Association between dietary antioxidant vitamins intake/blood level and risk of gastric cancer. Int. J. Cancer, 2014, 135(6), 1444-1453. doi: 10.1002/ijc.28777 PMID: 24510802
  64. Larsson, S.C.; Bergkvist, L.; Näslund, I.; Rutegård, J.; Wolk, A.; Vitamin, A. retinol, and carotenoids and the risk of gastric cancer: A prospective cohort study. Am. J. Clin. Nutr., 2007, 85(2), 497-503. doi: 10.1093/ajcn/85.2.497 PMID: 17284749
  65. Botterweck, A.A.M.; van den Brandt, P.A.; Goldbohm, R.A. Vitamins, carotenoids, dietary fiber, and the risk of gastric carcinoma. Cancer, 2000, 88(4), 737-748. doi: 10.1002/(SICI)1097-0142(20000215)88:4<737:AID-CNCR2>3.0.CO;2-H PMID: 10679641
  66. Smith-Warner, S.A.; Elmer, P.J.; Tharp, T.M.; Fosdick, L.; Randall, B.; Gross, M.; Wood, J.; Potter, J.D. Increasing vegetable and fruit intake: Randomized intervention and monitoring in an at-risk population. Cancer Epidemiol. Biomarkers Prev., 2000, 9(3), 307-317. PMID: 10750670
  67. Green, A.S.; Fascetti, A.J. Meeting the vitamin A requirement: The efficacy and importance of β -Carotene in animal species. Sci. World J., 2016, 2016, 7393620. doi: 10.1155/2016/7393620 PMID: 27833936
  68. Nishiwaki, R.; Okuno, M.; Moriwaki, H. Beta-carotene. Jpn. J. Clin. Med., 2004, 62, 141-144. PMID: 15658284
  69. Park, Y. Choi, J.; Lim, J.W.; Kim, H. β-Carotene-induced apoptosis is mediated with loss of Ku proteins in gastric cancer AGS cells. Genes Nutr., 2015, 10(4), 17. doi: 10.1007/s12263-015-0467-1 PMID: 25981694
  70. Jang, S.H.; Lim, J.W.; Kim, H. Mechanism of beta-carotene-induced apoptosis of gastric cancer cells: involvement of ataxia-telangiectasia-mutated. Ann. N. Y. Acad. Sci., 2009, 1171(1), 156-162. doi: 10.1111/j.1749-6632.2009.04711.x PMID: 19723050
  71. Kim, Y. Seo, J.H.; Kim, H. β-Carotene and lutein inhibit hydrogen peroxide-induced activation of NF-κB and IL-8 expression in gastric epithelial AGS cells. J. Nutr. Sci. Vitaminol., 2011, 57(3), 216-223. doi: 10.3177/jnsv.57.216 PMID: 21908944
  72. Lu, L. Chen, J.; Li, M.; Tang, L.; Wu, R.; Jin, L.; Liang, Z. β carotene reverses tobacco smoke induced gastric EMT via Notch pathway in vivo. Oncol. Rep., 2018, 39(4), 1867-1873. doi: 10.3892/or.2018.6246 PMID: 29393400
  73. Danesh, J. Helicobacter pylori infection and gastric cancer: Systematic review of the epidemiological studies. Aliment. Pharmacol. Ther., 1999, 13(7), 851-856. doi: 10.1046/j.1365-2036.1999.00546.x PMID: 10383517
  74. González, C.A.; López-Carrillo, L. Helicobacter pylori, nutrition and smoking interactions: Their impact in gastric carcinogenesis. Scand. J. Gastroenterol., 2010, 45(1), 6-14. doi: 10.3109/00365520903401959 PMID: 20030576
  75. Park, Y.; Lee, H.; Lim, J.W.; Kim, H. Inhibitory effect of β-carotene on Helicobacter pylori-induced TRAF expression and hyper-proliferation in gastric epithelial cells. Antioxidants, 2019, 8(12), 637. doi: 10.3390/antiox8120637 PMID: 31835889
  76. Hwang, H.; Dwyer, J.; Russell, R.M. Diet, Helicobacter pylori infection, food preservation and gastric cancer risk: Are there new roles for preventative factors? Nutr. Rev., 1994, 52(3), 75-83. doi: 10.1111/j.1753-4887.1994.tb01394.x PMID: 8015750
  77. Kim, H.J.; Kim, M.K.; Chang, W.K.; Choi, H.S.; Choi, B.Y.; Lee, S.S. Effect of nutrient intake and Helicobacter pylori infection on gastric cancer in Korea: A case-control study. Nutr. Cancer, 2005, 52(2), 138-146. doi: 10.1207/s15327914nc5202_4 PMID: 16201845
  78. Abnet, C.C.; Qiao, Y.L.; Dawsey, S.M.; Buckman, D.W.; Yang, C.S.; Blot, W.J.; Dong, Z.W.; Taylor, P.R.; Mark, S.D. Prospective study of serum retinol, beta-carotene, beta-cryptoxanthin, and lutein/zeaxanthin and esophageal and gastric cancers in China. Cancer Causes Control, 2003, 14(7), 645-655. doi: 10.1023/A:1025619608851 PMID: 14575362
  79. Yang, T.; Yang, X.; Wang, X.; Wang, Y.; Song, Z. The role of tomato products and lycopene in the prevention of gastric cancer: A meta-analysis of epidemiologic studies. Med. Hypotheses, 2013, 80(4), 383-388. doi: 10.1016/j.mehy.2013.01.005 PMID: 23352874
  80. Grabowska, M.; Wawrzyniak, D.; Rolle, K. Chomczyński, P.; Oziewicz, S.; Jurga, S.; Barciszewski, J. Let food be your medicine: Nutraceutical properties of lycopene. Food Funct., 2019, 10(6), 3090-3102. doi: 10.1039/C9FO00580C PMID: 31120074
  81. Luo, C.; Wu, X.G. Lycopene enhances antioxidant enzyme activities and immunity function in N-methyl-N'-nitro-N-nitrosoguanidine-enduced gastric cancer rats. Int. J. Mol. Sci., 2011, 12(5), 3340-3351. doi: 10.3390/ijms12053340 PMID: 21686188
  82. Kim, M.J.; Kim, H. Anticancer effect of lycopene in gastric carcinogenesis. J. Cancer Prev., 2015, 20(2), 92-96. doi: 10.15430/JCP.2015.20.2.92 PMID: 26151041
  83. Velmurugan, B.; Bhuvaneswari, V.; Nagini, S. Antiperoxidative effects of lycopene during N-methyl-N′-nitro-N-nitrosoguanidine-induced gastric carcinogenesis. Fitoterapia, 2002, 73(7-8), 604-611. doi: 10.1016/S0367-326X(02)00216-2 PMID: 12490218
  84. Costa-Rodrigues, J.; Pinho, O.; Monteiro, P.R.R. Can lycopene be considered an effective protection against cardiovascular disease? Food Chem., 2018, 245, 1148-1153. doi: 10.1016/j.foodchem.2017.11.055 PMID: 29287334
  85. Song, B.; Liu, K.; Gao, Y.; Zhao, L.; Fang, H.; Li, Y.; Pei, L.; Xu, Y. Lycopene and risk of cardiovascular diseases: A meta-analysis of observational studies. Mol. Nutr. Food Res., 2017, 61(9), 1601009. doi: 10.1002/mnfr.201601009 PMID: 28318092
  86. Zhou, S.; Zhang, R.; Bi, T.; Lu, Y.; Jiang, L. Inhibitory effect of lycopene against the growth of human gastric cancer cells. Afr. J. Tradit. Complement. Altern. Med., 2016, 13(4), 184-190. doi: 10.21010/ajtcam.v13i4.24 PMID: 28852735
  87. Zhang, B.; Gu, Y. Low expression of ERK signaling pathway affecting proliferation, cell cycle arrest and apoptosis of human gastric HGC-27 cells line. Mol. Biol. Rep., 2014, 41(6), 3659-3669. doi: 10.1007/s11033-014-3230-6 PMID: 24554029
  88. Han, H.; Lim, J.W.; Kim, H. Lycopene Inhibits activation of epidermal growth factor receptor and expression of cyclooxygenase-2 in gastric cancer cells. Nutrients, 2019, 11(9), 2113. doi: 10.3390/nu11092113 PMID: 31491956
  89. Kim, M.; Kim, S.H.; Lim, J.W.; Kim, H. Lycopene induces apoptosis by inhibiting nuclear translocation of β-catenin in gastric cancer cells. J. Physiol. Pharmacol., 2019, 70(4) PMID: 31741457
  90. Park, B.; Lim, J.W.; Kim, H. Lycopene treatment inhibits activation of Jak1/Stat3 and Wnt/β-catenin signaling and attenuates hyperproliferation in gastric epithelial cells. Nutr. Res., 2019, 70, 70-81. doi: 10.1016/j.nutres.2018.07.010 PMID: 30098838
  91. Jia, Y.P.; Sun, L.; Yu, H.S.; Liang, L.P.; Li, W.; Ding, H.; Song, X.B.; Zhang, L.J. The pharmacological effects of lutein and zeaxanthin on visual disorders and cognition diseases. Molecules, 2017, 22(4), 610. doi: 10.3390/molecules22040610 PMID: 28425969
  92. Giordano, E.; Quadro, L. Lutein, zeaxanthin and mammalian development: Metabolism, functions and implications for health. Arch. Biochem. Biophys., 2018, 647, 33-40. doi: 10.1016/j.abb.2018.04.008 PMID: 29654731
  93. Johnson, E.J. Role of lutein and zeaxanthin in visual and cognitive function throughout the lifespan. Nutr. Rev., 2014, 72(9), 605-612. doi: 10.1111/nure.12133 PMID: 25109868
  94. Wu, M.; Feng, Z.; Deng, Y.; Zhong, C.; Liu, Y.; Liu, J.; Zhao, X.; Fu, Y. Liquid antisolvent precipitation: An effective method for ocular targeting of lutein esters. Int. J. Nanomedicine, 2019, 14, 2667-2681. doi: 10.2147/IJN.S194068 PMID: 31043780
  95. Sindhu, E.R.; Kuttan, R. Carotenoid lutein protects rats from gastric ulcer induced by ethanol. J. Basic Clin. Physiol. Pharmacol., 2012, 23(1), 33-37. doi: 10.1515/jbcpp-2011-0032 PMID: 22865447
  96. Borlinghaus, J.; Albrecht, F.; Gruhlke, M.; Nwachukwu, I.; Slusarenko, A. Allicin: Chemistry and biological properties. Molecules, 2014, 19(8), 12591-12618. doi: 10.3390/molecules190812591 PMID: 25153873
  97. Luo, R.; Fang, D.; Hang, H.; Tang, Z. The mechanism in gastric cancer chemoprevention by allicin. Anticancer. Agents Med. Chem., 2016, 16(7), 802-809. doi: 10.2174/1871520616666151111115443 PMID: 26555611
  98. Ayaz, E.; Alpsoy, H.C. Garlic (Allium sativum) and traditional medicine. Turkiye Parazitol. Derg., 2007, 31(2), 145-149. PMID: 17594659
  99. Zhang, W.; Ha, M.; Gong, Y.; Xu, Y.; Dong, N.; Yuan, Y. Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways. Oncol. Rep., 2010, 24(6), 1585-1592. PMID: 21042755
  100. Sun, L.; Wang, X. Effects of allicin on both telomerase activity and apoptosis in gastric cancer SGC-7901 cells. World J. Gastroenterol., 2003, 9(9), 1930-1934. doi: 10.3748/wjg.v9.i9.1930 PMID: 12970878
  101. Zhang, Z.D.; Li, Y.; Jiao, Z.K. Effect of local application of allicin via gastroscopy on cell proliferation and apoptosis of progressive gastric carcinoma Chinese J. Integrat. Trad. Western Medic., 2008, 28(2), 108-110.
  102. Tao, M.; Gao, L.; Pan, J.; Wang, X. Study on the inhibitory effect of allicin on human gastric cancer cell line sgc-7901 and its mechanism. Afr. J. Tradit. Complement. Altern. Med., 2013, 11(1), 176-179. doi: 10.4314/ajtcam.v11i1.28 PMID: 24653574
  103. Vanduchova, A.; Anzenbacher, P.; Anzenbacherova, E. Isothiocyanate from Broccoli, sulforaphane, and its properties. J. Med. Food, 2019, 22(2), 121-126. doi: 10.1089/jmf.2018.0024 PMID: 30372361
  104. Choi, Y.H. ROS-mediated activation of AMPK plays a critical role in sulforaphane-induced apoptosis and mitotic arrest in AGS human gastric cancer cells. Gen. Physiol. Biophys., 2018, 37(2), 129-140. doi: 10.4149/gpb_2017026 PMID: 29593120
  105. Jiang, X.; Liu, Y.; Ma, L.; Ji, R.; Qu, Y.; Xin, Y.; Lv, G. Chemopreventive activity of sulforaphane. Drug Des. Devel. Ther., 2018, 12, 2905-2913. doi: 10.2147/DDDT.S100534 PMID: 30254420
  106. Fahey, J.W.; Haristoy, X.; Dolan, P.M.; Kensler, T.W.; Scholtus, I.; Stephenson, K.K.; Talalay, P.; Lozniewski, A. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo apyrene-induced stomach tumors. Proc. Natl. Acad. Sci. USA, 2002, 99(11), 7610-7615. doi: 10.1073/pnas.112203099 PMID: 12032331
  107. Yanaka, A. Sulforaphane enhances protection and repair of gastric mucosa against oxidative stress in vitro, and demonstrates anti-inflammatory effects on Helicobacter pylori-infected gastric mucosae in mice and human subjects. Curr. Pharm. Des., 2011, 17(16), 1532-1540. doi: 10.2174/138161211796196945 PMID: 21548875
  108. Yanaka, A.; Fahey, J.W.; Fukumoto, A.; Nakayama, M.; Inoue, S.; Zhang, S.; Tauchi, M.; Suzuki, H.; Hyodo, I.; Yamamoto, M. Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. Cancer Prev. Res., 2009, 2(4), 353-360. doi: 10.1158/1940-6207.CAPR-08-0192 PMID: 19349290
  109. Rauf, A.; Patel, S.; Imran, M.; Maalik, A.; Arshad, M.U.; Saeed, F.; Mabkhot, Y.N.; Al-Showiman, S.S.; Ahmad, N.; Elsharkawy, E. Honokiol: An anticancer lignan. Biomed. Pharmacother., 2018, 107, 555-562. doi: 10.1016/j.biopha.2018.08.054 PMID: 30114639
  110. Xia, S.; Lin, H.; Liu, H.; Lu, Z.; Wang, H.; Fan, S.; Li, N. Honokiol attenuates sepsis-associated acute kidney injury via the inhibition of oxidative stress and inflammation. Inflammation, 2019, 42(3), 826-834. doi: 10.1007/s10753-018-0937-x PMID: 30680694
  111. Liao, K.; Sun, L. Roles of the Hsp90-calcineurin pathway in the antifungal activity of Honokiol. J. Microbiol. Biotechnol., 2018, 28(7), 1086-1093. doi: 10.4014/jmb.1801.01024 PMID: 29913547
  112. Talarek, S.; Listos, J.; Barreca, D.; Tellone, E.; Sureda, A.; Nabavi, S.F.; Braidy, N.; Nabavi, S.M. Neuroprotective effects of honokiol: From chemistry to medicine. Biofactors, 2017, 43(6), 760-769. doi: 10.1002/biof.1385 PMID: 28817221
  113. Liu, S.H.; Wang, K.B.; Lan, K.H.; Lee, W.J.; Pan, H.C.; Wu, S.M.; Peng, Y.C.; Chen, Y.C.; Shen, C.C.; Cheng, H.C.; Liao, K.K.; Sheu, M.L. Calpain/SHP-1 interaction by honokiol dampening peritoneal dissemination of gastric cancer in nu/nu mice. PLoS One, 2012, 7(8), e43711. doi: 10.1371/journal.pone.0043711 PMID: 22937084
  114. Sheu, M.L.; Liu, S.H.; Lan, K.H. Honokiol induces calpain-mediated glucose-regulated protein-94 cleavage and apoptosis in human gastric cancer cells and reduces tumor growth. PLoS One, 2007, 2(10), e1096. doi: 10.1371/journal.pone.0001096 PMID: 17971859
  115. Liu, S.H.; Lee, W.J.; Lai, D.W.; Wu, S.M.; Liu, C.Y.; Tien, H.R.; Chiu, C.S.; Peng, Y.C.; Jan, Y.J.; Chao, T.H.; Pan, H.C.; Sheu, M.L. Honokiol confers immunogenicity by dictating calreticulin exposure, activating ER stress and inhibiting epithelial-to-mesenchymal transition. Mol. Oncol., 2015, 9(4), 834-849. doi: 10.1016/j.molonc.2014.12.009 PMID: 25619450
  116. Yan, B.; Peng, Z.Y. Honokiol induces cell cycle arrest and apoptosis in human gastric carcinoma MGC-803 cell line. Int. J. Clin. Exp. Med., 2015, 8(4), 5454-5461. PMID: 26131123
  117. Liu, J.; Lee, J.; Salazar Hernandez, M.A.; Mazitschek, R.; Ozcan, U. Treatment of obesity with celastrol. Cell, 2015, 161(5), 999-1011. doi: 10.1016/j.cell.2015.05.011 PMID: 26000480
  118. Venkatesha, S.H.; Dudics, S.; Astry, B.; Moudgil, K.D. Control of autoimmune inflammation by celastrol, a natural triterpenoid. Pathog. Dis., 2016, 74(6), ftw059. doi: 10.1093/femspd/ftw059 PMID: 27405485
  119. Sha, M.; Ye, J.; Zhang, L.; Luan, Z.; Chen, Y.; Huang, J. Celastrol induces apoptosis of gastric cancer cells by miR-21 inhibiting PI3K/Akt-NF-κB signaling pathway. Pharmacology, 2014, 93(1-2), 39-46. doi: 10.1159/000357683 PMID: 24434352
  120. Sha, M.; Ye, J.; Zhang, L.; Luan, Z.; Chen, Y. Celastrol induces apoptosis of gastric cancer cells by miR-146a inhibition of NF-κB activity. Cancer Cell Int., 2013, 13(1), 50. doi: 10.1186/1475-2867-13-50 PMID: 23706078
  121. Sha, M.; Ye, J.; Luan, Z.; Guo, T.; Wang, B.; Huang, J. Celastrol induces cell cycle arrest by microRNA-21-mTOR-mediated inhibition p27 protein degradation in gastric cancer. Cancer Cell Int., 2015, 15(1), 101. doi: 10.1186/s12935-015-0256-3 PMID: 26500453
  122. Cheng, C.; Dong, W. Aloe-emodin induces endoplasmic reticulum stress-dependent apoptosis in colorectal cancer cells. Med. Sci. Monit., 2018, 24, 6331-6339. doi: 10.12659/MSM.908400 PMID: 30199885
  123. Guo, J.; Xiao, B.; Liu, Q.; Gong, Z.; Le, Y. Suppression of C-myc expression associates with anti-proliferation of aloe-emodin on gastric cancer cells. Cancer Invest., 2008, 26(4), 369-374. doi: 10.1080/07357900701788130 PMID: 18443957
  124. Chen, R.; Zhang, J.; Hu, Y.; Wang, S.; Chen, M.; Wang, Y. Potential antineoplastic effects of Aloe-emodin: A comprehensive review. Am. J. Chin. Med., 2014, 42(2), 275-288. doi: 10.1142/S0192415X14500189 PMID: 24707862
  125. Acevedo-Duncan, M.; Russell, C.; Patel, S.; Patel, R. Aloe-emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells. Int. Immunopharmacol., 2004, 4(14), 1775-1784. doi: 10.1016/j.intimp.2004.07.012 PMID: 15531293
  126. Guo, J.; Xiao, B.; Zhang, S.; Liu, D.; Liao, Y.; Sun, Q. Growth inhibitory effects of gastric cancer cells with an increase in S phase and alkaline phosphatase activity repression by aloe-emodin. Cancer Biol. Ther., 2007, 6(1), 85-88. doi: 10.4161/cbt.6.1.3553 PMID: 17172820
  127. Chihara, T.; Shimpo, K.; Beppu, H.; Yamamoto, N.; Kaneko, T.; Wakamatsu, K.; Sonoda, S. Effects of aloe-emodin and emodin on proliferation of the MKN45 human gastric cancer cell line. Asian Pac. J. Cancer Prev., 2015, 16(9), 3887-3891. doi: 10.7314/APJCP.2015.16.9.3887 PMID: 25987055
  128. Tian, J.; Liu, Y.; Chen, K. Ginkgo biloba extract in vascular protection: Molecular mechanisms and clinical applications. Curr. Vasc. Pharmacol., 2017, 15(6), 532-548. PMID: 28707602
  129. Li, Y.; Zhang, Y.; Wen, M.; Zhang, J.; Zhao, X.; Zhao, Y.; Deng, J. Ginkgo biloba extract prevents acute myocardial infarction and suppresses the inflammation- and apoptosis-regulating p38 mitogen-activated protein kinases, nuclear factor-κB and B-cell lymphoma 2 signaling pathways. Mol. Med. Rep., 2017, 16(3), 3657-3663. doi: 10.3892/mmr.2017.6999 PMID: 28713946
  130. Singh, S.K.; Srivastav, S.; Castellani, R.J.; Plascencia-Villa, G.; Perry, G. Neuroprotective and antioxidant effect of Ginkgo biloba extract against AD and other neurological disorders. Neurotherapeutics, 2019, 16(3), 666-674. doi: 10.1007/s13311-019-00767-8 PMID: 31376068
  131. Qian, Y.; Xia, L.; Shi, W.; Sun, J.J.; Sun, Y.Q. The effect of EGB on proliferation of gastric carcinoma SGC7901 cells. Clin. Transl. Oncol., 2016, 18(5), 521-526. doi: 10.1007/s12094-015-1399-3 PMID: 26489423
  132. Liu, S.Q.; Xu, C.Y.; Qin, M.B.; Tan, L.; Zhuge, C.F.; Mao, Y.B.; Lai, M.Y.; Huang, J. Ginkgo biloba extract enhances chemotherapy sensitivity and reverses chemoresistance through suppression of the KSR1-mediated ERK1/2 pathway in gastric cancer cells. Oncol. Rep., 2015, 33(6), 2871-2882. doi: 10.3892/or.2015.3923 PMID: 25962735
  133. Fu, Z.; Lin, L.; Liu, S.; Qin, M.; He, S.; Zhu, L.; Huang, J. Ginkgo Biloba extract inhibits metastasis and ERK/Nuclear Factor kappa B (NF-κB) signaling pathway in gastric cancer. Med. Sci. Monit., 2019, 25, 6836-6845. doi: 10.12659/MSM.915146 PMID: 31509521
  134. Iwasaki, Y.; Matsui, T.; Arakawa, Y. The protective and hormonal effects of proanthocyanidin against gastric mucosal injury in Wistar rats. J. Gastroenterol., 2004, 39(9), 831-837. doi: 10.1007/s00535-004-1399-5 PMID: 15565401
  135. Rossi, M.; Rosato, V.; Bosetti, C.; Lagiou, P.; Parpinel, M.; Bertuccio, P.; Negri, E.; La Vecchia, C. Flavonoids, proanthocyanidins, and the risk of stomach cancer. Cancer Causes Control, 2010, 21(10), 1597-1604. doi: 10.1007/s10552-010-9588-4 PMID: 20521092
  136. Nie, C.; Zhou, J.; Qin, X.; Shi, X.; Zeng, Q.; Liu, J.; Yan, S.; Zhang, L. Reduction of apoptosis by proanthocyanidin-induced autophagy in the human gastric cancer cell line MGC-803. Oncol. Rep., 2016, 35(2), 649-658. doi: 10.3892/or.2015.4419 PMID: 26572257
  137. Lim, S.C.; Hwang, H.; Han, S.I. Ellagic acid inhibits extracellular acidity-induced invasiveness and expression of COX1, COX2, snail, twist 1, and c-myc in gastric carcinoma cells. Nutrients, 2019, 11(12), 3023. doi: 10.3390/nu11123023 PMID: 31835645
  138. Jang, M.G.; Ko, H.C.; Kim, S.J. Effects of p-coumaric acid on microRNA expression profiles in SNU-16 human gastric cancer cells. Genes Genomics, 2020, 42(7), 817-825. doi: 10.1007/s13258-020-00944-6 PMID: 32462517
  139. Najafi, M.; Mortezaee, K.; Rahimifard, M.; Farhood, B.; Haghi-Aminjan, H. The role of curcumin/curcuminoids during gastric cancer chemotherapy: A systematic review of non-clinical study. Life Sci., 2020, 257, 118051. doi: 10.1016/j.lfs.2020.118051 PMID: 32634426
  140. Mann, J. Natural products in cancer chemotherapy: Past, present and future. Nat. Rev. Cancer, 2002, 2(2), 143-148. doi: 10.1038/nrc723 PMID: 12635177
  141. Cao, A.L.; Tang, Q.F.; Zhou, W.C.; Qiu, Y.Y.; Hu, S.J.; Yin, P.H. Ras/ERK signaling pathway is involved in curcumin-induced cell cycle arrest and apoptosis in human gastric carcinoma AGS cells. J. Asian Nat. Prod. Res., 2015, 17(1), 56-63. doi: 10.1080/10286020.2014.951923 PMID: 25492214
  142. Uehara, Y.; Inoue, M.; Fukuda, K.; Yamakoshi, H.; Hosoi, Y.; Kanda, H.; Oshima, M.; Iwabuchi, Y.; Shibata, H. Inhibition of β-catenin and STAT3 with a curcumin analog suppresses gastric carcinogenesis in vivo. Gastric Cancer, 2015, 18(4), 774-783. doi: 10.1007/s10120-014-0434-3 PMID: 25331984
  143. Choudhary, S.; Singh, P.K.; Verma, H.; Singh, H.; Silakari, O. Success stories of natural product-based hybrid molecules for multi-factorial diseases. Eur. J. Med. Chem., 2018, 151, 62-97. doi: 10.1016/j.ejmech.2018.03.057 PMID: 29605809
  144. Salminen, A.; Lehtonen, M.; Suuronen, T.; Kaarniranta, K.; Huuskonen, J. Terpenoids: Natural inhibitors of NF-κB signaling with anti-inflammatory and anticancer potential. Cell. Mol. Life Sci., 2008, 65(19), 2979-2999. doi: 10.1007/s00018-008-8103-5 PMID: 18516495
  145. Lee, C.Y.; Yang, J.J.; Lee, S.S.; Chen, C.J.; Huang, Y.C.; Huang, K.H.; Kuan, Y.H. Protective effect of Ginkgo biloba leaves extract, EGb761, on endotoxin-induced acute lung injury via a JNK- and Akt-dependent NFκB pathway. J. Agric. Food Chem., 2014, 62(27), 6337-6344. doi: 10.1021/jf501913b PMID: 24956234
  146. Wang, R.; Shao, X.; Yang, J.; Liu, Z.; Chew, L.; Shao, Y. Ginkgo biloba extract mechanism inhibits hepatocellular carcinoma through the nuclear factor-κB/p53 signaling pathway. J. environ pathology, toxicology and oncology: Official organ Int. Soc. Environment. Toxicol Cancer, 2020, 39(2), 179-189.
  147. Zhang, L.; Li, G.; Tao, S.; Xia, P.; Chaudhry, N.; Kaura, S.; Stone, S.S.; Liu, M. Ginkgo biloba extract reduces cardiac and brain inflammation in rats fed a HFD and exposed to chronic mental stress through NF-κB inhibition. Mediators Inflamm., 2022, 2022, 1-15. doi: 10.1155/2022/2408598 PMID: 35677735
  148. Palozza, P.; Serini, S.; Torsello, A.; Di Nicuolo, F.; Maggiano, N.; Ranelletti, F.O.; Wolf, F.I.; Calviello, G. Mechanism of activation of caspase cascade during beta-carotene-induced apoptosis in human tumor cells. Nutr. Cancer, 2003, 47(1), 76-87. doi: 10.1207/s15327914nc4701_10 PMID: 14769541

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