STAT3 Signaling Axis and Tamoxifen in Breast Cancer: A Promising Target for Treatment Resistance

  • Авторлар: Zamanian M.Y.1, Golmohammadi M.2, Alalak A.3, Kamiab Z.4, Obaid R.5, Ramírez-Coronel A.6, Hjazi A.7, Abosaooda M.8, Mustafa Y.9, Heidari M.10, Verma A.11, Nazari Y.12, Bazmandegan G.13
  • Мекемелер:
    1. Department of Physiology, School of Medicine, Hamadan University of Medical Sciences
    2. Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences
    3. College of Pharmacy, Al-Bayan University
    4. Clinical Research Development Unit, Ali-Ibn Abi-Talib Hospital, Rafsanjan University of Medical Sciences
    5. Department of Biomedical Engineering, Al-Mustaqbal University College
    6. Health and Behavior Research Group (HBR), Psychometry and Ethology Laboratory, University of Cuenca
    7. Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University
    8. College of Pharmacy, the Islamic University
    9. Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul
    10. Department of Biochemistry, Institute of Biochemistry and Biophysics (IBB), University of Tehran
    11. Bioorganic and Medicinal Chemistry Research Laboratory, Department of Pharmaceutical Sciences, Sam Sam Higginbottom University of Agriculture, Technology and Sciences
    12. , Saveh University of Medical Sciences
    13. Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences
  • Шығарылым: Том 23, № 16 (2023)
  • Беттер: 1819-1828
  • Бөлім: Oncology
  • URL: https://filvestnik.nvsu.ru/1871-5206/article/view/694355
  • DOI: https://doi.org/10.2174/1871520623666230713101119
  • ID: 694355

Дәйексөз келтіру

Толық мәтін

Аннотация

Signal transducers and activators of transcription 3 (STAT 3) have been proposed to be responsible for breast cancer development. Moreover, evidence depicted that upregulation of STAT3 is responsible for angiogenesis, metastasis, and chemo-resistance of breast cancer. Tamoxifen (TAM) resistance is a major concern in breast cancer management which is mediated by numerous signaling pathways such as STAT3. Therefore, STAT3 targeting inhibitors would be beneficial in breast cancer treatment. The information on the topic in this review was gathered from scientific databases such as PubMed, Scopus, Google Scholar, and ScienceDirect. The present review highlights STAT3 signaling axis discoveries and TAM targeting STAT3 in breast cancer. Based on the results of this study, we found that following prolonged TAM treatment, STAT3 showed overexpression and resulted in drug resistance. Moreover, it was concluded that STAT3 plays an important role in breast cancer stem cells, which correlated with TAM resistance.

Негізгі сөздер

Авторлар туралы

Mohammad Zamanian

Department of Physiology, School of Medicine, Hamadan University of Medical Sciences

Email: info@benthamscience.net

Maryam Golmohammadi

Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences

Email: info@benthamscience.net

Ali Alalak

College of Pharmacy, Al-Bayan University

Email: info@benthamscience.net

Zahra Kamiab

Clinical Research Development Unit, Ali-Ibn Abi-Talib Hospital, Rafsanjan University of Medical Sciences

Email: info@benthamscience.net

Rasha Obaid

Department of Biomedical Engineering, Al-Mustaqbal University College

Email: info@benthamscience.net

Andrés Ramírez-Coronel

Health and Behavior Research Group (HBR), Psychometry and Ethology Laboratory, University of Cuenca

Email: info@benthamscience.net

Ahmed Hjazi

Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University

Email: info@benthamscience.net

Munther Abosaooda

College of Pharmacy, the Islamic University

Email: info@benthamscience.net

Yasser Mustafa

Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul

Email: info@benthamscience.net

Mahsa Heidari

Department of Biochemistry, Institute of Biochemistry and Biophysics (IBB), University of Tehran

Email: info@benthamscience.net

Amita Verma

Bioorganic and Medicinal Chemistry Research Laboratory, Department of Pharmaceutical Sciences, Sam Sam Higginbottom University of Agriculture, Technology and Sciences

Хат алмасуға жауапты Автор.
Email: info@benthamscience.net

Yashar Nazari

, Saveh University of Medical Sciences

Email: info@benthamscience.net

Gholamreza Bazmandegan

Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences

Хат алмасуға жауапты Автор.
Email: info@benthamscience.net

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